P-11: The Effects of Kerack Used in Iran on Sperm Parameters and Testis Structure in Adult Mice

Authors

  • Amini M
  • Farhoudian A
  • Rooghani M
  • Shirinbayan P
Abstract:

Background: Kerack is emerging illicit substance which its use is rising up in Iran. It has harmful effects on body organs. The aim of this study is to investigate the effects of Iranian Kerack on sperm parameters and testicular structure of mice. Materials and Methods: In this study, 25 male mice (Balb/C) were divided into five groups (control, sham and three experimental). Experimental groups of Kerackdependent mice (received ascending dose of Kerack for seven days twice daily) were divided into three categories, experimental I, II and III. Experimental I was given Kerack at a dose of 5 mg/kg, experimental II 35 mg/kg and experimental III 70 mg/kg, intraperitoneally twice a day for a period of 35 days. The sham group received normal saline and lemon juice (2.6 μl/ml) whilst the control group just received water and food. Mice were then scarified and sperm removed from cauda epididymis and analyzed for sperm count, motility, morphology (normal/ abnormal) and viability. Testes were also removed, weighed and processed for light microscopic studies. Results: The results showed that epididymal sperm parameters were significantly decreased in experimental groups (dose-dependent) compared with sham and control groups (p≤0.01). Gonadosomatic index and diameters of seminiferous tubules were significantly reduced with high dose Kerack (70 mg/kg) injected in comparison with control testes. Conclusion: It is concluded that Kerack used in Iran has the destructive effects on reproductive system in male mice.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

P-73: The Effects of Manganese on Testis Structure and Sperm Parameters in Adult Mice Exposed to Formaldehyde

Background: Formaldehyde (FA) as a ubiquitous environmental pollutant is extensively used in hospitals, laboratories and many industrial settings. FA exerts adverse effects on testicular structure and sperm param eters through increasing oxidative stress. Manganese, a well-known antioxidant, can inhibit oxidative stress damages. The aim of this study was to investigate the influences manganese ...

full text

the effects of changing roughness on the flow structure in the bends

flow in natural river bends is a complex and turbulent phenomenon which affects the scour and sedimentations and causes an irregular bed topography on the bed. for the reason, the flow hydralics and the parameters which affect the flow to be studied and understand. in this study the effect of bed and wall roughness using the software fluent discussed in a sharp 90-degree flume bend with 40.3cm ...

the impact of e-readiness on ec success in public sector in iran the impact of e-readiness on ec success in public sector in iran

acknowledge the importance of e-commerce to their countries and to survival of their businesses and in creating and encouraging an atmosphere for the wide adoption and success of e-commerce in the long term. the investment for implementing e-commerce in the public sector is one of the areas which is focused in government‘s action plan for cross-disciplinary it development and e-readiness in go...

P-76: Effects of Concurrent Ethanol and Saccharin Consumption on Sperm Parameters in Adult Mice

Background: Since sperm parameters have a critical role in reproductive function, the objective of this study was to evaluate the effects of concomitant ethanol and saccharin consumption on sperm parameters in adult mice. Chronic ethanol consumption suppresses male reproductive function and sexual behavior in laboratory animals and humans. Furthermore, alcohol abuse by males has been correlated...

full text

on translation of politeness strategies in dialogues involving female characters in translations and retranslations of novels translated before and after the islamic revolution of iran and their effects on the image of women: a polysystem theory approach

abstract reception environment has considerable effects on accepting a translation. as the expectations of a target culture and its values and needs change throughout history, its criteria for accepting a translation or rejecting it will change accordingly (gentzler, 2001). the expectations of iran, as the reception environment in the present study, have changed after the islamic revolution. i...

P-46: Effects of Different Doses of Ethanol on Sperm Parameters, ChromatinStructure and Apoptosis in Adult Mice

Background: Chronic ethanol abuse causes reproductive organ failure and infertility in both humans and laboratory animals. Since sperm has a critical role in reproductive function, the objective of this unique study was to evaluate the effects of different doses of ethanol on sperm parameters, chromatin structure and apoptosis in adult mice. Materials and Methods: A total of 36 adult male mice ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 6  issue 2

pages  -

publication date 2012-09-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023